GLUCOSAMINE SULFATE EFFICACY IN TREATING KNEE OSTEOARTHRITIS: A FOLLOW-UP STUDY.

Osteoarthritis (OA) can be treated using either a pharmacological or non-pharmacological approach, or a combination of both. The purpose of the present study was to investigate the efficacy of crystalline glucosamine sulfate (CGS) in patients with knee OA. This open-label prospective study (with a 12-month follow-up) included 111 patients of both genders suffering from knee OA, who attended the Special Hospital for Rheumatic Diseases in Novi Sad, Serbia during the 2011-2013 period. Patients were divided into the experimental (n=52) and the control (n=59) group. While the former was prescribed CGS 1500 mg/day, the latter was treated with nonsteroidal anti-inflammatory drugs (NSAIDs) according to the standard protocol. The efficacy of both treatment modes was assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Lequesne index, along with the radiological findings which involved knee joint space width (JSW) measurements. One year following the initial assessment, all patients reported pain intensity reduction; however, those in the CGS group experienced significantly lower pain intensity when compared with controls. At the end of the study, no reduction in the progression of joint structure damage (p>0.5) was noted in either group. Thus, while CGS demonstrated symptomatic efficacy, it failed to delay the progression of knee OA.

Uphill walking at iso-efficiency speeds.

Uphill walking gait has been extensively studied, but the optimal uphill speed able to enhance the metabolic demand without increasing fatigability has so far received little attention. Therefore, the aim of this study was to assess the metabolic/kinematic demand at constant speed (6 km·h-1 G0 level, G2 2% uphill, G7 7% uphill) and at iso-efficiency speeds (G2IES 5.2 km·h-1 2% uphill and G7IES 3.9 km·h-1 7% uphill). For this aim, physically active women (n:24, Age 33.40 ± 4.97 years, BMI 21.62 ± 2.06 kg/m-2) after an 8-min warm-up were studied on a treadmill for 10' for every walking condition with a 5' rest in between. Average heart rate (AVG-HR), rating of perceived exertion (RPE) and kinematic variables (stance time, swing time, stride length, stride cycle, stride-length variability, stride-cycle variability and internal work) were studied. Modifications in stance time, stride length and stride cycle (p<0.005), and lower internal-work values (p<0.001) occurred in G7IES in comparison to the other conditions. Swing time was significantly modified only in G7IES compared to G0 and G7 (p<0.001 and p<0.005, respectively). Stride-length variability and stride-cycle variability were higher in G7IES compared to the other conditions (p<0.001). G7 induced the highest AVG-HR (p<0.005) and RPE (p<0.001) compared to the other conditions. This study demonstrates that by applying the equation for uphill walking gait, it is possible to maintain a similar metabolic demand and RPE at iso-efficiency speeds during uphill compared to level walking, inducing at the same time a modification of the kinematic parameters of walking gait performed at the same slope condition.

Reproducibility of Internal and External Training Load During Recreational Small-Sided Football Games.

Purpose: The aim of this study was to evaluate the reproducibility of internal and external load parameters during recreational small-sided football games. Methods: Ten healthy untrained young adult males (age: 20.2 ± 1.9 yr, body mass: 69.2 ± 6.3 kg, height: 175.4 ± 5.9 cm, body fat: 19.7 ± 5.2%) performed two 2 × 20-min sessions of four versus four plus goalkeeper small-sided games (SSG) 1 week apart on a standard, outdoor, 40 × 20-m artificial grass pitch. Twelve external (total distance, peak speed, player load, work rate and distance covered at 0-2, 2-5, 5-7, 7-9, 9-13, 13-16, 16-20 and >20 km/h) and seven internal load parameters (heart rate and time spent in different heart rate zones [<70%, 71-80%, 81-90%, 91-95%, 96-100%, 91-100%]) were measured. Reproducibility was reported as intraclass coefficient correlation (ICC), the coefficient of variation (CV), and the typical error of measurements (TE). Results: No statistical differences (p> .05) between sessions were found in any measures. Minimal test-retest variability was noted for mean and peak heart rate (HRpeak) relative to HRpeak with CV values of 3.4% and 2.6%, respectively. Acceptable variability (CV<10%) was demonstrated for total distance covered, distance covered at 2-5 km/h, and peak speed. Distance covered in different speed zones (CV = 15.7-47.6%) and percentage of time in each HR zone showed large-to-very large variability (CV = 36.2-128.4%). Mean heart rate (HRmean), HRpeak, distance covered at 5-7, 13-16 and >20 km/h, and percentage of time above 95%HRpeak were the most reliable variables (ICC = 0.74-0.79), followed by total distance covered, peak speed, and percentage of time at 80-90% HRpeak (ICC = 0.39-0.67). The lowest reliability was observed for distance covered in the moderate speed zones 7-9 km/h (ICC = 0.12) and 9-13 km/h (ICC = -0.09), and percentage of time at 70-80% HRpeak (ICC = -0.01). Conclusions: Small-sided games can be used when planning training-induced exercise responses in relation to total distance covered, peak speed, and mean heart rate. This evidence further supports the use of SSG when organizing recreational football training, in young adult males, with the purpose of improving health profile due to the high reproducibility of HRmean and total distance covered.

Relative pitch area plays an important role in movement pattern and intensity in recreational male football.

Recreational football has been shown to be an effective health-promoting activity, but it is still unclear how changes in game formats affect external and internal load. The aim of this study was therefore to evaluate the effect of area per player in recreational small-sided football games. Ten recreational active male football participants (mean±standard deviation, age: 20.1±1.1 years; height: 182.2±7.4 cm; body mass: 75.9±9.8 kg) completed two sessions comprising 2x20 min of 5v5 football with 80 and 60 m2 per player, during which heart rate (HR) and movement pattern were measured. In 80 m2, mean HR (167±9 vs. 160±10 b.p.m., P<0.001, ES=0.70) and peak HR (192±8 vs. 188±9 b.p.m., P=0.041, ES=0.50) were significantly higher than in 60 m2. Percentage playing time with HR >90%HRpeak was higher in 80 m2 than 60 m2 (45±14 vs. 29±16%, P=0.004, ES=1.07). Moreover, a higher number of sprints (8.0±4.8 vs. 3.0±1.3, P=0.014, ES=1.41) and a greater distance in the highest speed zones (>13, >16 and >20 km·h1) were covered in 80 m2 than 60 m2. Peak running speed was also higher in 80 m2 (24.3±1.7 vs. 22.3±1.4 km·h-1, P=0.011, ES=1.27), whereas no statistically significant differences were found in total distance covered, player load, or the acceleration-deceleration profiles. In conclusion, the internal and external loading was higher for recreationally active male football players when playing on a pitch with 80 m2 area per player compared to 60 m2.

Lactate profile during greco-roman wrestling matchx.

The objective of this study was to determine and compare lactate profile of two groups of Greco-Roman wrestlers with different competences and training experience. Study was conducted on 10 wrestles that were members of Croatian national team and 10 wrestlers that were members of Wrestling club Split. Lactate samples were collected at four intervals during control fights that were held according to international wrestling rules of World wrestling federation FILA. Values of lactate increased as competition progressed, and they were highest at the end of the match for both groups of wrestlers. According to this study there were no significant differences in lactate between two groups at the end of the match, while significant differences were noted during the match. The information about lactate profile presented in this study can be used by coaches and wrestlers to develop condition programs. Key PointsThere were no significant differences in lactate concentrations at the end of the match between two proficiency levels of wrestlers.More proficient (elite) wrestlers raise lactates gradually through the wrestling match while less proficient (club) wrestlers raise it abruptly at the end of the first bout.Both groups of wrestlers are unable to sustain same level of activity through the match suggesting that they are utilizing too much energy from anaerobic glycolysis.

The impact of football training on motor development in male children.

The aim of the study was to determine the effect of football school program and physical education curriculum on changes in the motor abilities of 7- and 8-year-old boys. The study included a sample of 180 boys divided into group 1 (7-year-old boys), subdivided to experimental (n = 40) and control (n = 50) groups, and group 2 (8-year-old boys), subdivided to experimental (n = 40) and control (n = 50) groups. Experimental groups included children attending three training units of football training over a 9-month period, in addition to the conventional physical education curriculum. Control groups included children attending only conventional physical education curriculum. All study subjects underwent testing with a battery of 12 motor tests at the beginning and at the end of the study. Results obtained by discriminative canonic analysis showed no statistically significant between-group difference in motor abilities at the beginning of the study. However, significant differences in favor of experimental groups were recorded at the end of the study. Favorable changes in all motor variables were observed in both experimental and control groups of children from the initial through the final state. These changes were more pronounced in experimental groups. Analysis of variance for difference variables (final to initial measurement) indicated programmed education in the form of football training in addition to regular physical education curriculum to predominantly influence the development of aerobic endurance, agility, speed and flexibility in 7-year-old boys, and of explosive strength, aerobic endurance, flexibility and speed in 8-year-old boys. In the latter, football training led to the formation of a motor complex integrating explosiveness, speed, coordination, endurance and flexibility as a general motor factor determining future quality development in football.

Pulmonary function in persons who are professionally exposed to formaldehyde fumes.

The present study examines long-term effects of occupational exposure to formaldehyde fumes on lung function. Forced spirometry and diffusing lung capacity were measured in 16 health-service professionals (8 medical doctors and 8 laboratory technicians) working at the pathoanatomic laboratory for at least 4 years with daily exposure 8 +/- 1 hours. Control group employed 16 males, which were matched by age and stature to members of the exposed group. Only non-smokers were included in the study. Spirometric parameters in study participants exposed to formaldehyde fumes compared to control group were not significantly different indicating absence of restrictive and/or obstructive deterioration of lung function in exposed group. The only parameter differing in two groups was blood volume of pulmonary capillaries (Vc') which was significantly larger in a group exposed to formaldehyde fumes. The possibility that the hyperemic lung reaction is the consequence of the exposure to formaldehyde fumes should be further explored.

Influence of passive smoking on basic anthropometric characteristics and respiratory function in young athletes.

The primary objective of this study is to investigate the maintenance difference in basic anthropometric characteristics and to outline the dynamics of respiratory function change in youngsters athletes exposed to passive smoking (PS) and athletes not exposed to passive smoking in their families (NPS). High and weight were determined as basis anthropometric characteristics. Measured parameters for respiratory function were vital capacity (VC), forced expiratory volume in the first second (FEV1), maximum expiratory flow (PEF), forced expiratory flow at 50% forced vital capacity (MEF 50) and forced expiratory flow at 25% forced vital capacity (MEF 25). Significant statistical differences in separate spirometric variable were found in three variables (FEV1, MEF50, and MEF25) for group older youngsters. Analysis of variance showed statistical differences between athletes unexposed to passive smoking (NPS) and athletes exposed to passive smoking (PS) in even four spirometric variables (VC, FEV1, MEF50 and MEF25).